Feeding the Fibrillating Heart: Dichloroacetate Improves Cardiac Contractile
نویسندگان
چکیده
Feeding the Fibrillating Heart: Dichloroacetate Improves Cardiac Contractile 1 Dysfunction following VF 2 Running Title: DCA Treatment for VF Arrest 3 4 Mohammed Ali Azam, Cory S. Wagg, Stéphane Massé, Talha Farid, 5 Patrick F.H. Lai, Marjan Kusha, John Asta, Rafael Jaimes III, Sarah Kuzmiak-Glancy, 6 Matthew W. Kay, Gary D. Lopaschuk, Kumaraswamy Nanthakumar. 7 The Hull Family Cardiac Fibrillation Management Laboratory, University Health Network, 8 Toronto, Ontario, Canada, The Mazankowski Alberta Heart Institute, Edmonton, Alberta, 9 Canada, and The George Washington University, Washington, D.C., USA. 10 11 Address Correspondence to: 12 Kumaraswamy Nanthakumar, MD, FRCPc 13 The Hull Family Cardiac Fibrillation Management Laboratory 14 Division of Cardiology, University Health Network 15 Toronto General Hospital, 150 Gerrard Street West, GW3-526 16 Toronto, Ontario, Canada. M5G 2C4 17 Ph: (416) 340-4442Fax: (416) 340-4457 18 [email protected] 19 20 21 22 23 Articles in PresS. Am J Physiol Heart Circ Physiol (September 4, 2015). doi:10.1152/ajpheart.00404.2015
منابع مشابه
Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.
Ventricular fibrillation (VF) is an important cause of sudden cardiac arrest following myocardial infarction. Following resuscitation from VF, decreased cardiac contractile function is a common problem. During and following myocardial ischemia, decreased glucose oxidation, increased anaerobic glycolysis for cardiac energy production are harmful and energetically expensive. The objective of the ...
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